Trifluoroacetic acid → (S)-(Tetrahydro-pyran-3-yl)amine trifluoroacetate

HRID 246132Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 246132
C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][CH2:11][O:10][CH2:9]1)(C)(C)C.[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18]>ClCCl>[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18].[O:10]1[CH2:11][CH2:12][CH2:13][C@H:8]([NH2:7])[CH2:9]1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 67324694(S)-tert-butyl tetrahydro-2H-pyran-3-ylcarbamate

Produkt 1

HCID 71280724(S)-(Tetrahydro-pyran-3-yl)amine trifluoroacetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

(S)-(Tetrahydro-pyran-3-yl)-carbamic acid tert-butyl ester (42 mg, 0.21 mmol) was dissolved in dichloromethane (2.2 ml) and cooled in an ice bath. Trifluoroacetic acid (1.2 ml) was slowly added and the reaction was stirred at room temperature for 3 h then evaporated and dried under high vacuum to afford (S)-(Tetrahydro-pyran-3-yl)amine trifluoroacetate which was used without further purification.

Aufarbeitung

  1. temperaturecooled in an ice bath
  2. customthen evaporated
  3. customdried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-fff9c8c54d0e477aaaac4c38aa4d05de
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08658646B2

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