Trifluoroacetic acid → HCID 71280181, Verbindung

HRID 246280Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 246280
C(OC(=O)[NH:7][C:8]1([C:12]([OH:15])([CH3:14])[CH3:13])[CH2:11][CH2:10][CH2:9]1)(C)(C)C.[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20]>ClCCl>[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20].[NH2:7][C:8]1([C:12]([OH:15])([CH3:14])[CH3:13])[CH2:11][CH2:10][CH2:9]1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 712805461426423-60-0

Produkt 1

HCID 71280181HCID 71280181, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

In a 25 ml round-bottomed flask, [1-(1-hydroxy-1-methyl-ethyl)-cyclobutyl]-carbamic acid tert-butyl ester (150 mg, 0.65 mmol) was dissolved in dichloromethane (3.8 ml) and trifluoroacetic acid (1.5 ml, 19.5 mmol) was slowly added. The pale yellow reaction mixture was stirred at room temperature for 2.5 h then concentrated to give 2-(1-amino-cyclobutyl)-propan-2-ol trifluoroacetate as a light brown oil which was used without further purification.

Aufarbeitung

  1. concentrationthen concentrated

Quellen und Nachweise

ORD-Eintrag
ord-0f8391747d01459a998776a704523355
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08658646B2

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