2-Dimethylamino-6-methoxyphenylboronic acid → N-(2,6-dichlorobenzoyl)-4-[2-(N,N-dimethylamino)-6-methoxyphenyl]-L-phenylalanine methyl ester

HRID 24641

Reaktionsgleichung

Reaktionsgleichung von HRID 24641
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([N:9]([CH3:11])[CH3:10])[C:4]=1B(O)O.[CH3:15][O:16][C:17](=[O:38])[C@H:18]([CH2:30][C:31]1[CH:36]=[CH:35][C:34](Br)=[CH:33][CH:32]=1)[NH:19][C:20](=[O:29])[C:21]1[C:26]([Cl:27])=[CH:25][CH:24]=[CH:23][C:22]=1[Cl:28]>>[CH3:15][O:16][C:17](=[O:38])[C@H:18]([CH2:30][C:31]1[CH:32]=[CH:33][C:34]([C:4]2[C:3]([O:2][CH3:1])=[CH:8][CH:7]=[CH:6][C:5]=2[N:9]([CH3:11])[CH3:10])=[CH:35][CH:36]=1)[NH:19][C:20](=[O:29])[C:21]1[C:22]([Cl:28])=[CH:23][CH:24]=[CH:25][C:26]=1[Cl:27]

Komponenten

3

Edukt 2

HCID 43742582-Dimethylamino-6-methoxyphenylboronic acidHCID 54284267N-(2,6-dichlorobenzoyl)-4-bromo-L-phenylalanine methyl ester

Produkt 1

HCID 54467033N-(2,6-dichlorobenzoyl)-4-[2-(N,N-dimethylamino)-6-methoxyphenyl]-L-phenylalanine methyl ester

Versuchsvorschrift

2-Methoxy-6-(N,N-dimethylamino)benzene boronic acid was coupled with N-(2,6-dichlorobenzoyl)-4-bromo-L-phenylalanine methyl ester to give N-(2,6-dichlorobenzoyl)-4-[2-(N,N-dimethylamino)-6-methoxyphenyl]-L-phenylalanine methyl ester. The preparation of the boronic acid and the coupling reaction was carried out in a similar manner as described in Example 7.

Quellen und Nachweise

ORD-Eintrag
ord-96c7043f398846339ce0e3602e9d5816
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06855843B2

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