HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrochloric Acid → (S)-1-(5-(trifluoromethyl)-1H-imidazol-2-yl)ethanamine hydrochloride
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrochloric Acid | HCID 313 | — |
| Edukt | (S)-tert-butyl 1-(5-(trifluoromethyl)-1H-imidazol-2-yl)ethylcarbamate | HCID 71280415 | — |
| Lösungsmittel | 1,4-Dioxane | HCID 31275 | — |
| Produkt | (S)-1-(5-(trifluoromethyl)-1H-imidazol-2-yl)ethanamine hydrochloride | HCID 71279885 | — |
Reaktionsschritte
A solution of [(S)-1-(5-trifluoromethyl-1H-imidazol-2-yl)-ethyl]-carbamic acid tert-butyl ester (50 mg, 179 μmol) in 4M HCl in dioxane (2 mL) was stirred at room temperature for 15 h. The mixture was concentrated in vacuo then triturated with ether to give (S)-1-(5-trifluoromethyl-1H-imidazol-2-yl)-ethylamine hydrochloride (35 mg, quantitative) as a yellow oil. LCMS, [M+H]=180.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08658646B2 |
| Quelldatensatz | uspto-grants-2014_02 |
| ORD ID | ord-88c914026c9440bfbb921eb358b02c00 |
| Quellennotiz | uspto-grants-2014_02 |