Hydrochloric Acid → (S)-1-(5-(trifluoromethyl)-1H-imidazol-2-yl)ethanamine hydrochloride

HRID 246552

Reaktionsgleichung

Reaktionsgleichung von HRID 246552
C(OC(=O)[NH:7][C@H:8]([C:10]1[NH:11][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:13][N:14]=1)[CH3:9])(C)(C)C.[ClH:20]>O1CCOCC1>[ClH:20].[F:18][C:15]([F:16])([F:17])[C:12]1[NH:11][C:10]([C@@H:8]([NH2:7])[CH3:9])=[N:14][CH:13]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 71280415(S)-tert-butyl 1-(5-(trifluoromethyl)-1H-imidazol-2-yl)ethylcarbamate

Produkt 1

HCID 71279885(S)-1-(5-(trifluoromethyl)-1H-imidazol-2-yl)ethanamine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A solution of [(S)-1-(5-trifluoromethyl-1H-imidazol-2-yl)-ethyl]-carbamic acid tert-butyl ester (50 mg, 179 μmol) in 4M HCl in dioxane (2 mL) was stirred at room temperature for 15 h. The mixture was concentrated in vacuo then triturated with ether to give (S)-1-(5-trifluoromethyl-1H-imidazol-2-yl)-ethylamine hydrochloride (35 mg, quantitative) as a yellow oil. LCMS, [M+H]=180.

Aufarbeitung

  1. concentrationThe mixture was concentrated in vacuo
  2. customthen triturated with ether

Quellen und Nachweise

ORD-Eintrag
ord-88c914026c9440bfbb921eb358b02c00
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08658646B2

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