Hydrochloric Acid → Tert-butyl 3-amino-3-methylcyclobutylcarbamate hydrochloride

HRID 246668Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 246668
CC(C)(S([NH:6][C:7]1([CH3:19])[CH2:10][CH:9]([NH:11][C:12](=[O:18])[O:13][C:14]([CH3:17])([CH3:16])[CH3:15])[CH2:8]1)=O)C.[ClH:21]>CO.O1CCOCC1>[ClH:21].[NH2:6][C:7]1([CH3:19])[CH2:10][CH:9]([NH:11][C:12](=[O:18])[O:13][C:14]([CH3:16])([CH3:15])[CH3:17])[CH2:8]1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 71280661Tert-butyl 3-(1,1-dimethylethylsulfinamido)-3-methylcyclobutylcarbamate

Produkt 1

HCID 71280568Tert-butyl 3-amino-3-methylcyclobutylcarbamate hydrochlorideAusbeute 63 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

To a stirred solution of tert-butyl 3-(1,1-dimethylethylsulfinamido)-3-methylcyclobutylcarbamate (0.45 g, 1.48 mmol) in 150 mL of MeOH was added 2N HCl in dioxane (1.8 mL). The solution was stirred at room temperature overnight. The solvent was removed under reduced pressure, and the residue was triturated with EtOAc, then decanted and dried to give tert-butyl 3-amino-3-methylcyclobutylcarbamate hydrochloride (0.22 g, 63%) as a white solid. MS: (M+H)+=201.2; 1H NMR (300 MHz, DMSO): δ 2.24-2.22 (m, 1H), 1.43-1.383 (m, 13H), 1.10 (s, 3H).

Aufarbeitung

  1. customThe solvent was removed under reduced pressure
  2. customthe residue was triturated with EtOAc
  3. customdecanted
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-e678869c937c4fa4814edcac208e18ae
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08658646B2

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