StartseiteMCPWorkbenchSkills
StartseiteWorkbenchBenachrichtigungenMein Bereich
llms.txt · MCP-AnleitungDatenschutz · Nutzungsbedingungen · Supportv1.8.0
  1. Startseite
  2. /Reaktion

5-isopropyl-1-methyl-3-(tributylstannyl)-1H-indazole → (7-(tert-butylcarbamoyl)-2-(5-isopropyl-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazin-5-yl)methyl pivalate

HRID 246769
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 246769
[CH:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[N:9]([CH3:13])[N:8]=[C:7]2[Sn](CCCC)(CCCC)CCCC)([CH3:3])[CH3:2].[C:27]([O:33][CH2:34][N:35]1[C:39]2=[N:40][CH:41]=[C:42](Br)[N:43]=[C:38]2[C:37]([C:45](=[O:51])[NH:46][C:47]([CH3:50])([CH3:49])[CH3:48])=[CH:36]1)(=[O:32])[C:28]([CH3:31])([CH3:30])[CH3:29]>CN(C=O)C.[Cu]I.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[C:27]([O:33][CH2:34][N:35]1[C:39]2=[N:40][CH:41]=[C:42]([C:7]3[C:6]4[C:10](=[CH:11][CH:12]=[C:4]([CH:1]([CH3:2])[CH3:3])[CH:5]=4)[N:9]([CH3:13])[N:8]=3)[N:43]=[C:38]2[C:37]([C:45](=[O:51])[NH:46][C:47]([CH3:50])([CH3:49])[CH3:48])=[CH:36]1)(=[O:32])[C:28]([CH3:31])([CH3:30])[CH3:29]
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

6

Edukt 2

HCID 712803365-isopropyl-1-methyl-3-(tributylstannyl)-1H-indazoleHCID 86677996(2-bromo-7-(tert-butylcarbamoyl)-5H-pyrrolo[2,3-b]pyrazin-5-yl)methyl pivalate

Produkt 1

HCID 71279754(7-(tert-butylcarbamoyl)-2-(5-isopropyl-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazin-5-yl)methyl pivalate

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)
Katalysator
HCID 178418397HCID 178418397, VerbindungKatalysator
HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A mixture 5-isopropyl-1-methyl-3-(tributylstannyl)-1H-indazole, (2-bromo-7-(tert-butylcarbamoyl)-5H-pyrrolo[2,3-b]pyrazin-5-yl)methyl pivalate (0.408 g, 1 mmol), CuI (0.06 g, 0.32 mmol) and Pd(PPh3)4 (0.06 g, 0.052 mmol) in 40 mL of DMF was stirred at 80° C. under nitrogen for 4 hours. The solvent was removed under reduced pressure and the residue was triturated with water (15 mL) and petroleum ether (30 mL) then decanted and dried to give crude (7-(tert-butylcarbamoyl)-2-(5-isopropyl-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazin-5-yl)methyl pivalate (0.15 g) as a yellow solid, which was used into next step without further purification. LCMS: (M+H)+=505.

Aufarbeitung

  1. customThe solvent was removed under reduced pressure
  2. customthe residue was triturated with water (15 mL) and petroleum ether (30 mL)
  3. customthen decanted
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-dfbfe25959414b4080d3f4f04b9697b6
Quelldatensatz
uspto-grants-2014_02
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US08658646B2

Notizen zur Reaktion

Wird geladen…

Auf dieser SeiteKomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion