1-(Cyanomethyl)-3,5-dimethoxybenzene → 1-Bromo-2,4-dimethoxy-6-cyanobenzene

HRID 24709

Reaktionsgleichung

Reaktionsgleichung von HRID 24709
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:11][CH3:12])[CH:10]=1)[C:6]#[N:7].[Br-:13].[Br-].[Br-].[NH+]1C=CC=CC=1.[NH+]1C=CC=CC=1.[NH+]1C=CC=CC=1>C(Cl)Cl>[Br:13][C:4]1[C:5]([C:6]#[N:7])=[CH:8][C:9]([O:11][CH3:12])=[CH:10][C:3]=1[O:2][CH3:1]

Komponenten

4

Edukt 2

HCID 294821-(Cyanomethyl)-3,5-dimethoxybenzeneHCID 21124087Pyridiniumtribromide

Produkt 1

HCID 225718291-Bromo-2,4-dimethoxy-6-cyanobenzeneAusbeute 89,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 3,5-dimethoxybenzonitrile (2 g) in CH2Cl2 (100 mL) was added pyridinium tribromide (4 g). The mixture was stirred for 24 h at room temperature then washed successively with aqueous NaHCO3, water and brine, dried (MgSO4) filtered and evaporated. The residue was crystallized from CH2Cl2 and hexane to yield the title compound (1.8 g).

Aufarbeitung

  1. washthen washed successively with aqueous NaHCO3, water and brine
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. customevaporated
  5. customThe residue was crystallized from CH2Cl2 and hexane

Quellen und Nachweise

ORD-Eintrag
ord-27cbedddaa434946b43587b7aee9fe3e
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06855843B2

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