Benzaldehyde → HCID 135833470, Verbindung

Beteiligte Stoffe

Reaktionsschritte

A mixture of 500 mg of the oxadiazole intermediate prepared above, 240 mg of benzaldehyde and 260 mg of methyl 3-aminocrotonate in 5 ml of isopropyl alcohol was heated under reflux for 8 hours and then concentrated to dryness in vacuo. The residue was chromatographed on silica gel using chloroform-methanol (20:1, v/v) as eluent to give 600 mg of methyl 1,4-dihydro-2,6-dimethyl-3-(3-piperidinomethyl-1,2,4-oxadiazol-5-yl)-4-phenylpyridine-5-carboxylate as pale yellow crystals, mp. 187°-188° C. (decomp.).

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