4-Fluorobenzoic Acid → 4-Fluorobenzoic acid, 3-fluorophenyl ester

HRID 247186

Reaktionsgleichung

Reaktionsgleichung von HRID 247186
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1>COCCOCCOCCOCCOC>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][C:4]2[CH:5]=[CH:9][CH:10]=[C:2]([F:1])[CH:3]=2)=[O:7])=[CH:4][CH:3]=1

Komponenten

3

Edukt 1

HCID 99734-Fluorobenzoic Acid

Produkt 1

HCID 141493914-Fluorobenzoic acid, 3-fluorophenyl esterAusbeute 1,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8925TetraglymeLösungsmittel

Reaktionsbedingungen

Temperatur
240 °C

Versuchsvorschrift

A 25-ml Kjeldahl flask fitted with an air-cooling line was charged with 1.4 g of p-flurobenzoic acid, 0.976 g of cupric hydroxide, and 3 ml of tetraglyme as solvent, after which it was heated at 240° C. over an oil bath. This temperature was maintained for 60 minutes. After cooling, the reaction mixture was eluted with diethyl ether followed by filtration using Celite. the resulting filtrate was then submitted to column chromatography (solid phase: silica gel, developing solvent: hexane→methylene chloride) to give 0.013 g of m-fluorophenyl p-fluorobenzoate.

Aufarbeitung

  1. customA 25-ml Kjeldahl flask fitted with an air-cooling line
  2. temperatureThis temperature was maintained for 60 minutes
  3. temperatureAfter cooling
  4. washthe reaction mixture was eluted with diethyl ether
  5. filtrationfollowed by filtration

Quellen und Nachweise

ORD-Eintrag
ord-e7eec9de80b243ba891dc68229b2903d
Quelldatensatz
uspto-grants-1987_11
Patentnummer
US04705884

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