Diketene → Acetoacetic acid N-[4-(6-oxo-1,4,5,6-tetrahydropyridazin-3yl)-phenyl]-amide

HRID 247366

Reaktionsgleichung

Reaktionsgleichung von HRID 247366
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:13][CH2:12][C:11](=[O:14])[NH:10][N:9]=2)=[CH:4][CH:3]=1.[CH2:15]=[C:16]1[O:20][C:18](=[O:19])[CH2:17]1>CN(C)C=O>[O:14]=[C:11]1[NH:10][N:9]=[C:8]([C:5]2[CH:4]=[CH:3][C:2]([NH:1][C:18](=[O:19])[CH2:17][C:16]([CH3:15])=[O:20])=[CH:7][CH:6]=2)[CH2:13][CH2:12]1

Komponenten

4

Edukt 2

HCID 12661DiketeneHCID 6767506-(4-Aminophenyl)-4,5-dihydropyridazin-3(2H)-one

Produkt 1

HCID 13646979Acetoacetic acid N-[4-(6-oxo-1,4,5,6-tetrahydropyridazin-3yl)-phenyl]-amide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

20 g (0.106 mole) of 3-(4-aminophenyl)-6-oxo-1,4,5,6-tetrahydropyridazine in 250 ml of dimethylformamide are stirred with 9.47 g (0.113 moles) of diketene for 12 hours at room temperature. After the mixture has been concentrated, the residue is boiled up with 100 ml of ethanol, and the product is filtered off after cooling.

Aufarbeitung

  1. concentrationAfter the mixture has been concentrated
  2. filtrationthe product is filtered off
  3. temperatureafter cooling

Quellen und Nachweise

ORD-Eintrag
ord-06341a1303b7490f95e684614b1007ea
Quelldatensatz
uspto-grants-1987_11
Patentnummer
US04707479

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