3-(3,5-Difluorophenyl)propyl azide → 3-(3,5-Difluorophenyl)propan-1-amine
Reaktionsgleichung
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][CH2:11][N:12]=[N+]=[N-])[CH:5]=[C:6]([F:8])[CH:7]=1>CO>[F:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][CH2:11][NH2:12])[CH:5]=[C:6]([F:8])[CH:7]=1Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
3-(3,5-Difluorophenyl)propylazide (0.034 mol) in methanol (75 ml) was shaken with a slurry of methanol washed Raney nickel under 50 psi hydrogen for 2 hours. The reaction mixture was filtered and the filtrate concentrated to yield 5.6 g (96%) of an oily product.
Aufarbeitung
- washwashed Raney nickel under 50 psi hydrogen for 2 hours
- filtrationThe reaction mixture was filtered
- concentrationthe filtrate concentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-b73a0a6bafe14f6ab1fa8ea9c460fcb3
- Quelldatensatz
- uspto-grants-1987_11
- Patentnummer
- US04707488
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