3-Aminobenzonitrile → HCID 178509847, Verbindung

HRID 24804

Reaktionsgleichung

Reaktionsgleichung von HRID 24804
C([N:9]1[C:17]2[C:12](=[CH:13][C:14]([N+:18]([O-:20])=[O:19])=[CH:15][CH:16]=2)[C:11](=[C:21](O)[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:10]1=[O:29])(=O)C1C=CC=CC=1.[NH2:30][C:31]1[CH:32]=[C:33]([CH:36]=[CH:37][CH:38]=1)[C:34]#[N:35]>CN(C=O)C>[C:34]([C:33]1[CH:32]=[C:31]([NH:30]/[C:21](=[C:11]2\[C:10](=[O:29])[NH:9][C:17]3[C:12]\2=[CH:13][C:14]([N+:18]([O-:20])=[O:19])=[CH:15][CH:16]=3)/[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:38]=[CH:37][CH:36]=1)#[N:35]

Komponenten

4

Edukt 2

HCID 167023-AminobenzonitrileHCID 178516550HCID 178516550, Verbindung

Produkt 1

HCID 178509847HCID 178509847, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

2 g (5.2 mmol) of 1-benzoyl-3-(1-hydroxy-1-phenyl-methylidene)-5-nitro-2-indolinone and 1.8 g (16 mmol) of 3-aminobenzonitrile are stirred in DMF for 70 hours at ambient temperature. Then the reaction solution is extracted with ether, the organic phase is washed with water and dried over sodium sulphate. After removal of the solvent in vacuo the residue is chromatographed on silica gel (dichloromethane/methanol=50:1).

Aufarbeitung

  1. extractionThen the reaction solution is extracted with ether
  2. washthe organic phase is washed with water
  3. dry with materialdried over sodium sulphate
  4. customAfter removal of the solvent in vacuo the residue
  5. customis chromatographed on silica gel (dichloromethane/methanol=50:1)

Quellen und Nachweise

ORD-Eintrag
ord-bdb4ef81648c47fd8675561909d34a08
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06855710B2

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