Hydrochloric Acid → Diethyl methyl-(4-amino)benzylmalonate

HRID 248063Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 248063
[CH3:1][C:2]([CH2:13][C:14]1[CH:19]=[CH:18][C:17]([NH:20]C(=O)C)=[CH:16][CH:15]=1)([C:8]([O:10][CH2:11][CH3:12])=[O:9])[C:3]([O:5][CH2:6][CH3:7])=[O:4].Cl.C(=O)([O-])O>>[CH3:1][C:2]([CH2:13][C:14]1[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][CH:15]=1)([C:8]([O:10][CH2:11][CH3:12])=[O:9])[C:3]([O:5][CH2:6][CH3:7])=[O:4]

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 769Bicarbonate IonHCID 54008305Diethyl methyl-(4-acetamido)benzylmalonate

Produkt 1

HCID 54055855Diethyl methyl-(4-amino)benzylmalonate

Versuchsvorschrift

Mix diethyl methyl-(4-acetamido)benzylmalonate (5.01 g, 15.6 mmol) and 2N hydrochloric acid (65 mL) and heat at reflux for several hours. Cool to room temperature, basify with solid hydrogen carbonate and extract into ethyl ether (3×). Dry (MgSO4) and evaporate the solvent in vacuo to give diethyl methyl-(4-amino)benzylmalonate.

Aufarbeitung

  1. temperatureheat
  2. temperatureat reflux for several hours
  3. extractionextract into ethyl ether (3×)
  4. dry with materialDry (MgSO4)
  5. customevaporate the solvent in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-05b0ce8b6270496ab4525a8a2b7e8ddd
Quelldatensatz
uspto-grants-1993_05
Patentnummer
US05208240

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