1-Naphthol → (2R)-1-(butyryloxy)-3-(1-naphthyloxy)-2-propanol

Beteiligte Stoffe

Reaktionsschritte

To a solution of 144 g (1 mol) of 1-naphthol and 7.4 g (0.02 mol) of tetrabutylammonium iodide in 200 ml of toluene was added 144 g (1 mol) of (R)-glycidyl butyrate over a period of 15 min at a temperature of 120° C., and the mixture was kept at this temperature for a further 4 h. Conventional subsequent treatment of the reaction mixture gave the required compound as an oil, yield about 75%.

Herkunft & Nachweise