HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Ammonium Hydroxide → 2-Chloroadenosine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Ammonium Hydroxide | HCID 14923 | — |
| Edukt | 9-(2',3',5'-O-triacetyl-b-D-ribofuranosyl)-2,6-dichloropurine | HCID 131717899 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | 2-Chloroadenosine | HCID 8974 | — |
Reaktionsschritte
A mixture of the compound of Example 3 (271 g, 606 M), concentrated ammonium hydroxide (4 L) and tetrahydrofuran (0.5 L) is stirred at room temperature under nitrogen for 4 days. The solvent volume is reduced in vacuo and the resulting residue is triturated with absolute ethanol. The title compound is precipitated out of the ethanolic solvent to yield a light brown solid, (159 g, 87%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05208327 |
| Quelldatensatz | uspto-grants-1993_05 |
| ORD ID | ord-48f537549a924049abcf925e59802984 |
| Quellennotiz | uspto-grants-1993_05 |