Propargyl alcohol → Nonadec-2-yn-1-ol

HRID 248149

Reaktionsgleichung

Reaktionsgleichung von HRID 248149
[CH2:1]([OH:4])[C:2]#[CH:3].[Li].[CH2:6](Br)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]>O1CCCC1.N>[CH2:1]([OH:4])[C:2]#[C:3][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH3:6]

Komponenten

6

Edukt 3

HCID 7859Propargyl alcoholHCID 82131-BromohexadecaneHCID 3028194Lithium

Produkt 1

HCID 10967930Nonadec-2-yn-1-ol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 222AmmoniaLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of 56.1 g of propargyl alcohol in 100 ml of tetrahydrofuran and 15.6 g of lithium in 1 liter of ammonia containing a trace of ferric chloride is stirred for 1 hour. A 76.4 ml portion of hexadecyl bromide is added and the mixture refluxed for 8 hours then evaporated. The residue is dissolved in ether and washed with 10% hydrochloric acid, dried and purified by flash chromatography, to give 47.4 g of the desired compound as white platelets, mp. 60° C.

Aufarbeitung

  1. temperaturethe mixture refluxed for 8 hours
  2. customthen evaporated
  3. dissolutionThe residue is dissolved in ether
  4. washwashed with 10% hydrochloric acid
  5. customdried
  6. custompurified by flash chromatography

Quellen und Nachweise

ORD-Eintrag
ord-03ad03efdbea4d5a919894b5736fd45f
Quelldatensatz
uspto-grants-1993_05
Patentnummer
US05208223

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