Ammonia → 2,2-Difluoro-1-Methylcyclopropanecarboxamide

HRID 248221

Reaktionsgleichung

Reaktionsgleichung von HRID 248221
[NH3:1].[F:2][C:3]1([F:10])[CH2:5][C:4]1([CH3:9])[C:6](Cl)=[O:7]>O1CCOCC1>[F:2][C:3]1([F:10])[CH2:5][C:4]1([C:6]([NH2:1])=[O:7])[CH3:9]

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 146952322,2-Difluoro-1-methylcyclopropane-1-carbonyl chloride

Produkt 1

HCID 146952362,2-Difluoro-1-MethylcyclopropanecarboxamideAusbeute 81 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

Gaseous ammonia is passed for 90 minutes into a stirred solution of 15.45 g (0.1 mol) of 2,2-difluoro-1-methyl-cyclopropane-carbonyl chloride in 80 ml of dioxane at 20° to 30° C. The resultant suspension is then evaporated to dryness under a water pump vacuum. The residue remaining is stirred with 50 ml of water, filtered off with suction and dried. In this manner, 11 g (81% of theory) of 2,2-difluoro-1-methyl-cyclopropyl-carboxamide in form of a solid substance of melting point 125°-127° C. are obtained.

Aufarbeitung

  1. customThe resultant suspension is then evaporated to dryness under a water pump vacuum
  2. filtrationfiltered off with suction
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-c4c078dec5e3494b98b6169bc5475e93
Quelldatensatz
uspto-grants-1993_05
Patentnummer
US05208388

Verknüpfte Notizen

Wird geladen…