2-(1,1-Difluoroethyl)pyrazine → 2-(1,1-Difluoroethyl)piperazine

HRID 248532Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 248532
[F:1][C:2]([C:5]1[CH:6]=[N:7][CH:8]=[CH:9][N:10]=1)([F:4])[CH3:3].[H][H]>CO.[Pt]=O>[F:1][C:2]([CH:5]1[NH:10][CH2:9][CH2:8][NH:7][CH2:6]1)([F:4])[CH3:3]

Komponenten

5

Edukt 2

HCID 197635642-(1,1-Difluoroethyl)pyrazineHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 197635812-(1,1-Difluoroethyl)piperazine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 82844Platinum oxide (PtO)KatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A 4.3 g portion of 3-(1,1-difluoroethyl)pyrazine in 25 ml of methanol was reduced with 50 psi hydrogen and 750 mg of platinum oxide at 20° C. for 5 hours. The resulting oil was purified by chromatography, giving about 700 mg of 3-(1,1-difluoroethyl)piperazine.

Aufarbeitung

  1. customThe resulting oil was purified by chromatography

Quellen und Nachweise

ORD-Eintrag
ord-61ee99b124134599a18fa13e6ec7af1c
Quelldatensatz
uspto-grants-1993_05
Patentnummer
US05210193

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