Triethylamine → 3-[2-[N-(4-Fluoro-3-trifluoromethylphenyl)sulfamoyl]acetylamino]propionic Acid Ethyl Ester

HRID 248728Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 248728
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][S:9]([CH2:12][C:13]([OH:15])=O)(=[O:11])=[O:10])=[CH:4][C:3]=1[C:16]([F:19])([F:18])[F:17].[OH2:20].[OH:21][C:22]1[C:30]2N=N[NH:27][C:26]=2C=CC=1.C(N([CH2:36][CH3:37])CC)C.C1(N=C=NC2CCCCC2)CCCCC1>>[CH2:36]([O:20][C:22](=[O:21])[CH2:30][CH2:26][NH:27][C:13](=[O:15])[CH2:12][S:9](=[O:10])(=[O:11])[NH:8][C:5]1[CH:6]=[CH:7][C:2]([F:1])=[C:3]([C:16]([F:19])([F:18])[F:17])[CH:4]=1)[CH3:37]

Komponenten

5

Edukt 4

HCID 8471TriethylamineHCID 10868DicyclohexylcarbodiimideHCID 197640082-[N-(4-fluoro-3-trifluoromethylphenyl)sulfamoyl]acetic acidHCID 178526939HCID 178526939, Verbindung

Produkt 1

HCID 156765793-[2-[N-(4-Fluoro-3-trifluoromethylphenyl)sulfamoyl]acetylamino]propionic Acid Ethyl Ester

Versuchsvorschrift

Under the conditions of Example 2(a), 3.012 g (10 mmol) of 2-[N-(4-fluoro-3-trifluoromethylphenyl)sulfamoyl]acetic acid, 1.536 g (10 mmol) of β-alanine ethyl acid dimethyl ester hydrochloride, 1.531 g (10 mmol) of hydroxybenzotriazole, hydrate, as well as 1.012 g (10 mmol) of triethylamine and 2.063 g (10 mmol) of dicyclohexylcarbodiimide are reacted and worked up analogously. The crude product is chromatographed on silica gel. The title compound is eluted with ethyl acetate.

Aufarbeitung

  1. customThe crude product is chromatographed on silica gel
  2. washThe title compound is eluted with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-8029a948a8d345fc911aa3ebbc6f9cef
Quelldatensatz
uspto-grants-1993_05
Patentnummer
US05210290

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