Triethylamine → 2-[2-[N-(4-Fluoro-3-trifluoromethylphenyl)sulfamoyl]benzoylamino]-2-(1-hydroxyethyl)acetic Acid Ethyl Ester

HRID 248729

Reaktionsgleichung

Reaktionsgleichung von HRID 248729
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][S:9]([C:12]2[CH:20]=[CH:19][C:15](C(O)=O)=[CH:14][CH:13]=2)(=[O:11])=[O:10])=[CH:4][C:3]=1[C:21]([F:24])([F:23])[F:22].Cl.[CH2:26]([O:28][C:29](=[O:35])[C@H:30]([C@@H:32]([CH3:34])[OH:33])[NH2:31])[CH3:27].O.[OH:37][C:38]1C2N=NNC=2C=CC=1.C(N(CC)CC)C.C1(N=C=NC2CCCCC2)CCCCC1>>[CH2:26]([O:28][C:29](=[O:35])[CH:30]([NH:31][C:38](=[O:37])[C:13]1[CH:14]=[CH:15][CH:19]=[CH:20][C:12]=1[S:9](=[O:11])(=[O:10])[NH:8][C:5]1[CH:6]=[CH:7][C:2]([F:1])=[C:3]([C:21]([F:22])([F:24])[F:23])[CH:4]=1)[CH:32]([OH:33])[CH3:34])[CH3:27]

Komponenten

6

Edukt 5

HCID 8471TriethylamineHCID 10868DicyclohexylcarbodiimideHCID 2763096Ethyl L-threoninate hydrochlorideHCID 36999904-[N-(4-fluoro-3-trifluoromethylphenyl)sulfamoyl)benzoic acidHCID 178526939HCID 178526939, Verbindung

Produkt 1

HCID 156765822-[2-[N-(4-Fluoro-3-trifluoromethylphenyl)sulfamoyl]benzoylamino]-2-(1-hydroxyethyl)acetic Acid Ethyl Ester

Versuchsvorschrift

Under the conditions of Example 2(a), 3.633 g (10 mmol) of 4-[N-(4-Fluoro-3-trifluoromethylphenyl)sulfamoyl]benzoic acid, 1.736 g (10 mmol) of L-threonine ethyl ester hydrochloride, 1.531 g (10 mmol) of hydroxybenzotriazole, hydrate, as well as 1.012 g (10 mmol) of triethylamine and 2.063 g (10 mmol) of dicyclohexylcarbodiimide are reacted and worked up analogously. The crude product is chromatographed on silica gel. The title compound is eluted with ethyl acetate.

Aufarbeitung

  1. customThe crude product is chromatographed on silica gel
  2. washThe title compound is eluted with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-97698e87395e4adf8687f2c0fbc7cbbd
Quelldatensatz
uspto-grants-1993_05
Patentnummer
US05210290

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