[CH:1]1[CH:6]=[C:5]2[C:7]([N:9]([CH2:12][C:13](Cl)=[O:14])[C:10](=[O:11])[C:4]2=[CH:3][CH:2]=1)=[O:8].[Cl:16][C:17]1[CH:31]=[CH:30][C:20]2[O:21][C:22]3[CH:29]=[CH:28][CH:27]=[CH:26][C:23]=3[CH2:24][NH:25][C:19]=2[CH:18]=1.C(N(CC)CC)C.Cl>C1(C)C=CC=CC=1>[Cl:16][C:17]1[CH:31]=[CH:30][C:20]2[O:21][C:22]3[CH:29]=[CH:28][CH:27]=[CH:26][C:23]=3[CH2:24][N:25]([C:13](=[O:14])[CH2:12][N:9]3[C:7](=[O:8])[C:5]4[C:4](=[CH:3][CH:2]=[CH:1][CH:6]=4)[C:10]3=[O:11])[C:19]=2[CH:18]=11,3-dihydro-1,3-dioxo-2H-isoindole-2-acetyl chloride (4.00 grams), 8-chloro-10,11-dihydrodibenz[b,f][1,4]oxazepine (4.16 grams) and triethylamine (2.8 mL) were refluxed in toluene (100 mL) under nitrogen for 3 hours. The resulting mixture was poured into 1N HCl at 0° C., and the biphasic mixture was shaken vigorously. The insoluble product was collected by filtration, washed with toluene and ethyl ether, and dried in vacuo at 56° C. The yield of the title compound was 6.36 grams (85%). Mp: 184°-185° C.
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