2-(N-Benzyl-N-methylamino)-1-(N-piperidinyl)ethane → Methyl(2-(piperidin-1-yl)ethyl)amine

HRID 248874

Reaktionsgleichung

Reaktionsgleichung von HRID 248874
[CH2:1]([N:8]([CH2:10][CH2:11][N:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)C)C1C=CC=CC=1>CCO.[OH-].[OH-].[Pd+2]>[CH3:1][NH:8][CH2:10][CH2:11][N:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1

Komponenten

4

Edukt 1

HCID 232084362-(N-Benzyl-N-methylamino)-1-(N-piperidinyl)ethane

Produkt 1

HCID 3157473Methyl(2-(piperidin-1-yl)ethyl)amine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9942167Palladium hydroxideKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of the title compound of Step 11 (1.85 g, 7.96mmol) and 20% Pd(OH)2 on carbon in EtOH (50 mL) was placed under a hydrogen atmosphere (60 psi) at room temperature for 17 hours. The mixture was filtered and concentrated to give the title compound as a clear, yellow liquid (1.02 g, 90% crude yield). The proton spectral data were consistent with the proposed structure.

Aufarbeitung

  1. customat room temperature
  2. customfor 17 hours
  3. filtrationThe mixture was filtered
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-24f9471b682b46ea902a3d42b6b01974
Quelldatensatz
uspto-grants-1993_05
Patentnummer
US05212185

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