Thionyl Chloride → 3-(1-Adamantyl)-4-methoxybenzoyl chloride

HRID 249024

Reaktionsgleichung

Reaktionsgleichung von HRID 249024
[C:1]12([C:11]3[CH:12]=[C:13]([CH:17]=[CH:18][C:19]=3[O:20][CH3:21])[C:14](O)=[O:15])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.S(Cl)([Cl:24])=O>>[C:1]12([C:11]3[CH:12]=[C:13]([CH:17]=[CH:18][C:19]=3[O:20][CH3:21])[C:14]([Cl:24])=[O:15])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 52965033-(1-Adamantyl)-4-methoxybenzoic acid

Produkt 1

HCID 108044973-(1-Adamantyl)-4-methoxybenzoyl chlorideAusbeute 100 %

Versuchsvorschrift

In a round bottom flask, there are introduced 200 ml of thionyl chloride and there are then added, in small fractions, 35 g (122 mmoles) of the acid obtained in stage (a), above. The reaction mixture is heated to reflux until the emission of gases ceases. The reaction mixture is evaporated to dryness, taken up in 100 ml of anhydrous benzene and again evaporated to dryness, yielding 37 g of the expected product (100% yield) having a melting point of 153°-154° C.

Aufarbeitung

  1. temperatureThe reaction mixture is heated
  2. temperatureto reflux until the emission of gases ceases
  3. customThe reaction mixture is evaporated to dryness
  4. customagain evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-19110497a281468ea9a9a7cea488f338
Quelldatensatz
uspto-grants-1993_05
Patentnummer
US05212203

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