Sulfuric Acid → 5-Acetyl-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide

HRID 249091Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 249091
S(=O)(=O)(O)[OH:2].[C:6]([C:9]1[CH:10]=[C:11]([C:17]#[N:18])[C:12](=[O:16])[NH:13][C:14]=1[CH3:15])(=[O:8])[CH3:7]>>[C:6]([C:9]1[CH:10]=[C:11]([C:17]([NH2:18])=[O:2])[C:12](=[O:16])[NH:13][C:14]=1[CH3:15])(=[O:8])[CH3:7]

Komponenten

3

Edukt 2

HCID 1118Sulfuric AcidHCID 27654765-Acetyl-2-hydroxy-6-methylnicotinonitrile

Produkt 1

HCID 27644175-Acetyl-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

To 100 grams of concentrated sulfuric acid is added 10 g (0.056 mole) of 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile. The mixture is stirred at 60° C. for 5 hours, cooled and then poured on 1 kg ice. The resulting solid is collected, washed with water and recrystallized from ethanol to give the title compound.

Aufarbeitung

  1. temperaturecooled
  2. customThe resulting solid is collected
  3. washwashed with water
  4. customrecrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-156719c31b5447f1b2eee8711be17b48
Quelldatensatz
uspto-grants-1993_05
Patentnummer
US05212315

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