Isobutylbenzene → 4'-Isobutylhexanophenone

HRID 249183

Reaktionsgleichung

Reaktionsgleichung von HRID 249183
[Cl-].[Al+3].[Cl-].[Cl-].[C:5](Cl)(=[O:11])[CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].[CH2:13]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH:14]([CH3:16])[CH3:15]>ClCCl>[CH2:13]([C:17]1[CH:22]=[CH:21][C:20]([C:5](=[O:11])[CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])=[CH:19][CH:18]=1)[CH:14]([CH3:16])[CH3:15]

Komponenten

5

Edukt 3

HCID 10870IsobutylbenzeneHCID 67340Hexanoyl chlorideHCID 6451240Aluminum(III) Chloride

Produkt 1

HCID 108790194'-Isobutylhexanophenone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

To a suspension of aluminum chloride (6.67 g) in dichloromethane (70 ml) was added hexanoyl chloride (7.0 ml) at 0° C. After the mixture was stirred at 0° C. for 15 minutes, isobutylbenzene (7.9 ml) was added to the mixture. The mixture was stirred at 0° C. for 30 minutes and poured into ice water. The separated organic layer was washed with water, aqueous sodium bicarbonate and brine. The solution was dried over magnesium sulfate and evaporated to give 4'-isobutylhexanophenone (10.52 g) as a colorless oil.

Aufarbeitung

  1. stirringThe mixture was stirred at 0° C. for 30 minutes
  2. washThe separated organic layer was washed with water, aqueous sodium bicarbonate and brine
  3. dry with materialThe solution was dried over magnesium sulfate
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-deb06ca4e0e64b41a5ca817defb57461
Quelldatensatz
uspto-grants-1993_05
Patentnummer
US05212320

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