Dimethylformamide → 2-{4-[(3,5-Dichloropyridin-2-yl)oxy]phenoxy}propanoyl chloride

HRID 249200Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 249200
S(Cl)([Cl:3])=O.[Cl:5][C:6]1[C:7]([O:13][C:14]2[CH:25]=[CH:24][C:17]([O:18][CH:19]([CH3:23])[C:20](O)=[O:21])=[CH:16][CH:15]=2)=[N:8][CH:9]=[C:10]([Cl:12])[CH:11]=1.CN(C)C=O>C(Cl)(Cl)Cl>[Cl:5][C:6]1[C:7]([O:13][C:14]2[CH:25]=[CH:24][C:17]([O:18][CH:19]([CH3:23])[C:20]([Cl:3])=[O:21])=[CH:16][CH:15]=2)=[N:8][CH:9]=[C:10]([Cl:12])[CH:11]=1

Komponenten

5

Edukt 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 173715Chlorazifop

Produkt 1

HCID 131894782-{4-[(3,5-Dichloropyridin-2-yl)oxy]phenoxy}propanoyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Reaktionsbedingungen

Temperatur
63 °C

Versuchsvorschrift

Thionyl chloride (18.8 mL, 257.1 mmol) is added dropwise to a mixture of 2-{p-[(3,5-dichloro-2-pyridyl)oxy]phenoxy}propionic acid (21.1 g, 64.3 mmol) in chloroform (220 mL). When the addition is complete, dimethylformamide (1.5 mL) is added and the reaction mixture is stirred for 21 hours at 63° C., concentrated in vacuo and chased with chloroform to obtain the title product as a yellow syrup which is identified by 1H NMR spectral analysis.

Aufarbeitung

  1. additionWhen the addition
  2. concentrationconcentrated in vacuo and chased with chloroform

Quellen und Nachweise

ORD-Eintrag
ord-9c29c95b3e804780a4b286297116dea5
Quelldatensatz
uspto-grants-1993_05
Patentnummer
US05213606

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