Ethyl Acrylate → N-[1-(ethoxycarbonylethyl)-piperid-4-yl]-N-methylpropionamide

HRID 249340Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 249340
[C:1]([O:5][CH2:6][CH3:7])(=[O:4])[CH:2]=[CH2:3].[NH:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH3:19])[C:15](=[O:18])[CH2:16][CH3:17])[CH2:10][CH2:9]1>C(O)C>[CH2:6]([O:5][C:1]([CH2:2][CH2:3][N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH3:19])[C:15](=[O:18])[CH2:16][CH3:17])[CH2:10][CH2:9]1)=[O:4])[CH3:7]

Komponenten

4

Edukt 2

HCID 8821Ethyl AcrylateHCID 19761222N-Methyl-N-(piperidin-4-yl)propionamide

Produkt 1

HCID 19761283N-[1-(ethoxycarbonylethyl)-piperid-4-yl]-N-methylpropionamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Versuchsvorschrift

14 g of ethyl acrylate in 45 ml of ethanol are added dropwise to 23.8 of the amine obtained in Stage C of Example 1 dissolved in 45 ml of ethanol. The mixture is stirred at room temperature for 3 hours, evaporated, and the residual oil is distilled in a Kugelrohr (bulb tube) at 120° C. and 0.09 mm Hg.

Aufarbeitung

  1. customevaporated
  2. distillationthe residual oil is distilled in a Kugelrohr (bulb tube) at 120° C.

Quellen und Nachweise

ORD-Eintrag
ord-e1244c9aee924c7c884c2f9a00f1cf88
Quelldatensatz
uspto-grants-1993_05
Patentnummer
US05214055

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