Dimethylamine → N,N-dimethyl-2-(4-nitrophenoxy)ethanamine

HRID 24937

Reaktionsgleichung

Reaktionsgleichung von HRID 24937
Br[CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][CH:6]=1.[CH3:14][NH:15][CH3:16]>CN(C)C=O>[CH3:14][N:15]([CH3:16])[CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][CH:6]=1

Komponenten

4

Edukt 2

HCID 674DimethylamineHCID 2359871-(2-Bromoethoxy)-4-nitrobenzene

Produkt 1

HCID 887421N,N-dimethyl-2-(4-nitrophenoxy)ethanamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

4.9 g (20 mmol) of 4-(2-bromoethyloxy)-nitrobenzene and 2.7 g (60 mmol) of dimethylamine in 50 ml of dimethylformamide are heated to 100° C. for 24 hours in a bomb tube. After removal of the solvent in vacuo the residue is taken up in water and extracted with dichloromethane. The organic phase is dried and concentrated by evaporation.

Aufarbeitung

  1. customAfter removal of the solvent in vacuo the residue
  2. extractionextracted with dichloromethane
  3. customThe organic phase is dried
  4. concentrationconcentrated by evaporation

Quellen und Nachweise

ORD-Eintrag
ord-a8e4bf5abd1e4934998ac18b605dab70
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06855710B2

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