2-(5-Fluoro-3-hydroxyphenyl)-2-methoxybut-1-yl methyl ether → 2-[5-Fluoro-3-(7-fluoronaphth-2-ylmethoxy)phenyl]-2-methoxybut-1-yl methyl ether
Reaktionsgleichung
[CH3:1][O:2][CH2:3][C:4]([C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[C:11]([OH:16])[CH:10]=1)([O:7][CH3:8])[CH2:5][CH3:6].Br[CH2:18][C:19]1[CH:28]=[CH:27][C:26]2[C:21](=[CH:22][C:23]([F:29])=[CH:24][CH:25]=2)[CH:20]=1>>[CH3:1][O:2][CH2:3][C:4]([C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[C:11]([O:16][CH2:18][C:19]2[CH:28]=[CH:27][C:26]3[C:21](=[CH:22][C:23]([F:29])=[CH:24][CH:25]=3)[CH:20]=2)[CH:10]=1)([O:7][CH3:8])[CH2:5][CH3:6]Komponenten
3
Versuchsvorschrift
Using the procedure described in Example 12, 2-(5-fluoro-3-hydroxyphenyl)-2-methoxybut-1-yl methyl ether was reacted with 2-bromomethyl-7-fluoronaphthalene to give 2-[5-fluoro-3-(7-fluoronaphth2-ylmethoxy)phenyl]-2-methoxybut-1-yl methyl ether in 76% yield, as an oil.
Quellen und Nachweise
- ORD-Eintrag
- ord-dd086fcfed9e4e12b380e139e42ae728
- Quelldatensatz
- uspto-grants-1993_05
- Patentnummer
- US05214069
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