1,2-Bis(2-(tert-butyloxycarbonyl)aminooxyethoxy)ethane → Bis-aminooxy-PEG2

HRID 24957Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 24957
C(OC([NH:8][O:9][CH2:10][CH2:11][O:12][CH2:13][CH2:14][O:15][CH2:16][CH2:17][O:18][NH:19]C(OC(C)(C)C)=O)=O)(C)(C)C>CCOC(C)=O.Cl>[NH2:19][O:18][CH2:17][CH2:16][O:15][CH2:14][CH2:13][O:12][CH2:11][CH2:10][O:9][NH2:8]

Komponenten

4

Edukt 1

HCID 110362781,2-Bis(2-(tert-butyloxycarbonyl)aminooxyethoxy)ethane

Produkt 1

HCID 3306142Bis-aminooxy-PEG2Ausbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

Compound 36 (559 mg, 1.47 mmol) was dissolved in 15 mL of of EtOAc, and HCl gas was bubbled through the solution for 30 minutes. The mixture was concentrated under vacuum to provide 72 mg (90%) of compound 37 as the HCl salt as a sticky residue: 1H NMR (D2O) δ 3.75 (s, 4H), 3.87 (m, 4H), 4.27 (m, 4H); mass spectrum (ES) m/z calculated for C6H17N2O4 (M+H): 181.1. Found: 181.1.

Aufarbeitung

  1. customwas bubbled through the solution for 30 minutes
  2. concentrationThe mixture was concentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-c48368b2745445a4aaf4c31711b1143d
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06858210B1

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