Ethyl 4-Chloroquinoline-3-carboxylate → Ethyl 4-chloro-6,7-difluoroquinoline-3-carboxylate

HRID 249676

Reaktionsgleichung

Reaktionsgleichung von HRID 249676
[Cl:1]C1C2C(=CC=CC=2)N=CC=1C(OCC)=O.[F:17][C:18]1[CH:19]=[C:20]2[C:25](=[CH:26][C:27]=1[F:28])[N:24]=[CH:23][C:22]([C:29]([O:31][CH2:32][CH3:33])=[O:30])=[C:21]2O>>[Cl:1][C:21]1[C:20]2[C:25](=[CH:26][C:27]([F:28])=[C:18]([F:17])[CH:19]=2)[N:24]=[CH:23][C:22]=1[C:29]([O:31][CH2:32][CH3:33])=[O:30]

Komponenten

3

Edukt 2

HCID 268963Ethyl 4-Chloroquinoline-3-carboxylateHCID 178469610HCID 178469610, Verbindung

Produkt 1

HCID 1511944Ethyl 4-chloro-6,7-difluoroquinoline-3-carboxylate

Versuchsvorschrift

The title compound was prepared following the procedure described in Step 2 for the synthesis of 3a using 2c instead of 2a. 1H NMR (CDCl3) δ (ppm): 1.47 (3H, t, J=7.08 Hz), 4.56 (2H, q, J=7.08 Hz), 7.72 (1H, d, J=8.79 Hz), 8.39 (1H, d, J=8.78 Hz), 9.23 (1H, s). m/z 271.6/273.6 (M+/M+2). m/z 272.6 (MH+).

Quellen und Nachweise

ORD-Eintrag
ord-28805ef310544126840c05c3fc5c7d40
Quelldatensatz
uspto-grants-2011_01
Patentnummer
US07863266B2

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