Ethyl 4-Chloroquinoline-3-carboxylate → Ethyl 4-chloro-6-(trifluoromethyl)quinoline-3-carboxylate

HRID 249683

Reaktionsgleichung

Reaktionsgleichung von HRID 249683
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13].OC1C2C(=CC=C([C:28]([F:31])([F:30])[F:29])C=2)N=CC=1C(OCC)=O>>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:28]([F:31])([F:30])[F:29])[CH:10]=2)[N:5]=[CH:4][C:3]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13]

Komponenten

3

Edukt 2

HCID 268963Ethyl 4-Chloroquinoline-3-carboxylateHCID 178469538Ethyl 4-hydroxy-6-(trifluoromethyl)quinoline-3-carboxylate

Produkt 1

HCID 4322147Ethyl 4-chloro-6-(trifluoromethyl)quinoline-3-carboxylate

Versuchsvorschrift

The title compound was prepared following the procedure described in Step 2 for the synthesis of 3a using 2h instead of 2a. 1H NMR (CDCl3) δ (ppm): 1.46 (3H, t, J=7.14 Hz), 4.51 (2H, q, J=7.14 Hz), 8.00 (1H, dd, J=8.79, 1.92 Hz), 8.26 (1H, d, J=8.79 Hz), 8.78 (1H, dd, J=1.92, 0.83 Hz), 9.34 (1H, s). m/z 304.6 (MH+).

Quellen und Nachweise

ORD-Eintrag
ord-7836d803e22c4d1abc09c792d84da247
Quelldatensatz
uspto-grants-2011_01
Patentnummer
US07863266B2

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