HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hexane → (RS)-N-(Ethoxycarbonyl)-S-methyl-S-[3-({[6-methoxy-4-(3-pyridylamino)-quinazolin-7-yl]oxy}methyl)phenyl]sulphoximide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hexane | HCID 8058 | — |
| Edukt | 3-Aminopyridine | HCID 10009 | — |
| Edukt | Dichloromethane methanol | HCID 21226129 | — |
| Edukt | N'-(2-cyano-5-{3-[(RS)-N-(ethoxycarbonyl)-S-methylsulphonimidoyl]benzyloxy}-4-methoxyphenyl)-N,N-dimethylformimidamide | HCID 57788001 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | (RS)-N-(Ethoxycarbonyl)-S-methyl-S-[3-({[6-methoxy-4-(3-pyridylamino)-quinazolin-7-yl]oxy}methyl)phenyl]sulphoximide | HCID 57788050 | 55% |
Reaktionsschritte
According to GWP 5, the reaction of N′-(2-cyano-5-{3-[(RS)-N-(ethoxycarbonyl)-S-methylsulphonimidoyl]benzyloxy}-4-methoxyphenyl)-N,N-dimethylformimidamide (76 mg, 0.17 mmol) with 3-aminopyridine (19 mg, 0.20 mmol) and chromatographic purification (silica gel, amino column, hexane, dichloromethane/methanol: 0→5% methanol) gives the desired product in 55% yield (46 mg).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07863283B2 |
| Quelldatensatz | uspto-grants-2011_01 |
| ORD ID | ord-8d9bedcc75a24b3380c5db763a399fc9 |
| Quellennotiz | uspto-grants-2011_01 |