Hydrochloric Acid → 3-((4-(2-Fluorobenzyloxy)phenyl)-methylthio)propionic acid

HRID 25003

Reaktionsgleichung

Reaktionsgleichung von HRID 25003
[F:1][C:2]1[CH:24]=[CH:23][CH:22]=[CH:21][C:3]=1[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][S:13][CH2:14][CH2:15][C:16]([O:18]CC)=[O:17])=[CH:8][CH:7]=1.[OH-].[Na+].Cl>C(O)C>[F:1][C:2]1[CH:24]=[CH:23][CH:22]=[CH:21][C:3]=1[CH2:4][O:5][C:6]1[CH:7]=[CH:8][C:9]([CH2:12][S:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17])=[CH:10][CH:11]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 21964542Ethyl 3-((4-(2-fluorobenzyloxy)phenyl)-methylthio)propionate

Produkt 1

HCID 121322933-((4-(2-Fluorobenzyloxy)phenyl)-methylthio)propionic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of Ethyl 3-((4-(2-fluorobenzyloxy)phenyl)-methylthio)propionate (Step C, 0.122 g, 0.35 mmol) in ethanol (5 ml) was added 1N NaOH (0.5 ml) at room temperature. The reaction mixture was stirred for 3 hours, acidified with 1M HCl and concentrated in vacuo to give white solid which was purified by flash chromatography on silica gel column (chloroform: methanol, 92.5:7.5 spiked with acetic acid) to provide the title compound as a white solid.

Aufarbeitung

  1. concentrationconcentrated in vacuo
  2. customto give white solid which
  3. customwas purified by flash chromatography on silica gel column (chloroform: methanol, 92.5:7.5 spiked with acetic acid)

Quellen und Nachweise

ORD-Eintrag
ord-da0deb6842ee4508a350a9a18adece09
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06858602B2

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