Dimethylformamide → (+/-)-7-(4,5-Dihydro-5-methyl-4-oxo-thiazol-2-yl)-8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine

https://huagongshe.com/de/reaction/25069

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Dimethylformamide	HCID 6228	—
Edukt	Ethyl 2-bromopropionate	HCID 79040	—
Edukt	(+/-)-8-Methyl-5-(4-nitrophenyl)-7-thiocarbamoyl-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine	HCID 12137394	—
Lösungsmittel	Water	HCID 962	—
Produkt	(+/-)-7-(4,5-Dihydro-5-methyl-4-oxo-thiazol-2-yl)-8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine	HCID 12137432	95%

Reaktionsbedingungen

Temperatur	85 °C

Reaktionsschritte

A mixture of 1.00 g (2.60 mmol) of the starting material I, 0.94 g (5.19 mmol) of ethyl 2-bromopropionate and 10 ml of dimethylformamide was stirred at 80-90° C. for 2 h. After diluting with water the obtained crude product was purified by refluxing in 15 ml of ethanol to yield 1.08 g (95%) of the title compound; Mp.: 213-214° C.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US06858605B2
Quelldatensatz	uspto-grants-2005_02
ORD ID	ord-7485b3d401664163aaf0601da93eec85
Quellennotiz	uspto-grants-2005_02