Cyclopentylamine → HCID 86067038, Verbindung

HRID 250725Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 250725
[CH3:1][N:2]([O:15][CH3:16])[C:3](=[O:14])[C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[C:6](F)[CH:5]=1.[CH:17]1([NH2:22])[CH2:21][CH2:20][CH2:19][CH2:18]1.C(#N)C>Cl>[CH3:16][O:15][N:2]([CH3:1])[C:3](=[O:14])[C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[C:6]([NH:22][CH:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)[CH:5]=1

Komponenten

5

Edukt 3

HCID 2906CyclopentylamineHCID 6342AcetonitrileHCID 577580833-Fluoro-N-methoxy-N-methyl-4-nitrobenzamide

Produkt 1

HCID 86067038HCID 86067038, VerbindungAusbeute 92,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

Combine N-[methyl]N-[methoxy]3-fluoro-4-nitrobenzamide (2.3 g, 10 mmol), cyclopentylamine (12.3 mL, 100 mmol) and acetonitrile (50 mL) and stir at room temperature for 6 hours. Dilute with 1N HCl and extract with ethyl acetate. Wash the organic layer sequentially with water and saturated aqueous sodium chloride, then dry over magnesium sulfate. Concentrate under reduced pressure to provide the desired compound as an orange solid (2.7 g, 92%).

Aufarbeitung

  1. extractionextract with ethyl acetate
  2. washWash the organic layer sequentially with water and saturated aqueous sodium chloride
  3. dry with materialdry over magnesium sulfate
  4. concentrationConcentrate under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-47f792c7a0824ddcb95f086460f770ef
Quelldatensatz
uspto-grants-2011_01
Patentnummer
US07863310B2

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