HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 25082Erstellt: 25. Oktober 2026
Dimethylformamide → HCID 178421800, Verbindung
https://huagongshe.com/reaction/25082
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Dimethylformamide | HCID 6228 | — |
| Edukt | Ammonium Chloride | HCID 25517 | — |
| Edukt | Sodium Azide | HCID 33557 | — |
| Edukt | (+/-)-8-Methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbonitrile | HCID 12137416 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Produkt | HCID 178421800 | HCID 178421800 | 101,7% |
Reaktionsschritte
A mixture of 0.60 g (1.70 mmol) of the starting material XXIII, 3 ml of dimethylformamide, 0.12 g (1.87 mmol) of sodium azide and 0.10 g (1.87 mmol) of ammonium chloride was stirred at 140° C. for 30 min. The cooled reaction mixture was diluted with water and the precipitated crystals were filtered off. The so obtained product was purified by column chromatography using silica gel (MN Kieselgel 60) as adsorbent and a mixture of chloroform-methanol (99:1) as eluent to yield 0.68 g (54%) of the title compound; Mp.: 263-264° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US06858605B2 |
|---|
| Quelldatensatz | uspto-grants-2005_02 |
|---|
| ORD ID | ord-2ca105df26b446e984445b4e84d6a6c2 |
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| Quellennotiz | uspto-grants-2005_02 |
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