m-Chloroperbenzoic acid → 5-Fluoro-2,3-dimethyl-1-oxidopyridin-1-ium

HRID 250990Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 250990
[F:1][C:2]1[CH:3]=[N:4][C:5]([CH3:9])=[C:6]([CH3:8])[CH:7]=1.ClC1C=C(C=CC=1)C(OO)=[O:15]>C(Cl)Cl>[F:1][C:2]1[CH:3]=[N+:4]([O-:15])[C:5]([CH3:9])=[C:6]([CH3:8])[CH:7]=1

Komponenten

4

Edukt 2

HCID 70297m-Chloroperbenzoic acidHCID 450799815-Fluoro-2,3-dimethylpyridine

Produkt 1

HCID 197912325-Fluoro-2,3-dimethyl-1-oxidopyridin-1-ium

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A mixture of 3-fluoro-5,6-dimethyl-pyridine (0.230 g, 1.84 mmol) (Ife, R. J. Eur. Pat. Appl. (1987), EP 246774), 3-chloroperoxybenzoic acid (77%, 1.24 g, 5.5 mmol) in CH2Cl2 (25 mL) was stirred for 16 h. The solution was concentrated, and the residue was purified by flash chromatography on a silica gel column (8:1 EtOAc/MeOH), affording 3-fluoro-5,6-dimethyl-pyridine-1-oxide as a white solid (0.225 g 87%).

Aufarbeitung

  1. concentrationThe solution was concentrated
  2. customthe residue was purified by flash chromatography on a silica gel column (8:1 EtOAc/MeOH)

Quellen und Nachweise

ORD-Eintrag
ord-44f430289bd44a899ba65c34cbec79a8
Quelldatensatz
uspto-grants-2011_01
Patentnummer
US07863293B2

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