Sodium Hydroxide → Quetiapine

HRID 251397

Reaktionsgleichung

Reaktionsgleichung von HRID 251397
C([O:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][N:13]([C:16]2[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[S:20][C:19]3[CH:27]=[CH:28][CH:29]=[CH:30][C:18]=3[N:17]=2)[CH2:12][CH2:11]1)(=O)C.[OH-].[Na+]>C(O)C>[CH:24]1[CH:25]=[CH:26][C:21]2[S:20][C:19]3[CH:27]=[CH:28][CH:29]=[CH:30][C:18]=3[N:17]=[C:16]([N:13]3[CH2:14][CH2:15][N:10]([CH2:9][CH2:8][O:7][CH2:6][CH2:5][OH:4])[CH2:11][CH2:12]3)[C:22]=2[CH:23]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 11487114Quetiapine acetate

Produkt 1

HCID 5002QuetiapineAusbeute 98,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

The residue of 11-(4-[2-(2-acetyloxyethoxy)ethyl]-1-piperazinyl]dibenzo[b,f]-1,4-thiazepine (7.8 g) was dissolved in ethanol (50 ml) and 1M NaOH solution (55 ml) was added. The mixture was stirred at room temperature for 30 min. The product was extracted into toluene (2×100 ml). Evaporation of the toluene phase gave quetiapine base (6.9 g).

Aufarbeitung

  1. extractionThe product was extracted into toluene (2×100 ml)
  2. customEvaporation of the toluene phase

Quellen und Nachweise

ORD-Eintrag
ord-a5210979d7f94179863f210cad5b3ea0
Quelldatensatz
uspto-grants-2011_01
Patentnummer
US07863441B2

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