Piperazine → 1-(5-Nitropyridin-2-yl)piperazine

HRID 251423

Reaktionsgleichung

Reaktionsgleichung von HRID 251423
Br[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1.[NH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1>O1CCCC1>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([N:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)=[N:3][CH:4]=1)([O-:10])=[O:9]

Komponenten

4

Edukt 2

HCID 4837PiperazineHCID 782402-Bromo-5-nitropyridine

Produkt 1

HCID 29287991-(5-Nitropyridin-2-yl)piperazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

2-Bromo-5-nitropyridine (0.3 g, 1.48 mmol) was treated with piperazine (0.64 g, 7.89 mmol) in tetrahydrofuran (4 ml) and the reaction mixture was stirred for 30 minutes. Subsequently the reaction mixture was poured onto ice-cold water (25 ml) and extracted with ethyl acetate (25 ml). The organic layer was washed with brine and evaporated to furnish the product.

Aufarbeitung

  1. additionSubsequently the reaction mixture was poured onto ice-cold water (25 ml)
  2. extractionextracted with ethyl acetate (25 ml)
  3. washThe organic layer was washed with brine
  4. customevaporated
  5. customto furnish the product

Quellen und Nachweise

ORD-Eintrag
ord-46396960c5da454bbbfbc49490f48c2d
Quelldatensatz
uspto-grants-2011_01
Patentnummer
US07863446B2

Verknüpfte Notizen

Wird geladen…