HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
6-Amino-3-chloropyridazine → 3-(6-Chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 6-Amino-3-chloropyridazine | HCID 21643 | — |
| Edukt | 3-(2-Bromoacetyl)benzonitrile | HCID 2735867 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | 3-(6-Chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile | HCID 46835564 | 52,8% |
Reaktionsschritte
A solution of 3-(2-bromoacetyl)benzonitrile and 6-chloropyridazin-3-amine (1 mmol) in EtOH was heated to reflux overnight. Then the mixture was cooled to r.t., and the precipitate was filtered to give 3-(6-chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile with a yield of 52.8%.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07868001B2 |
| Quelldatensatz | uspto-grants-2011_01 |
| ORD ID | ord-bb6d0969b60c4f5089b1237cf88c97de |
| Quellennotiz | uspto-grants-2011_01 |