HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-(6-Chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile → 3-(Imidazo[1,2-b]pyridazin-2-yl)benzonitrile
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-(6-Chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile | HCID 46835564 | — |
| Katalysator | Palladium | HCID 23938 | — |
| Lösungsmittel | tetrahydrofuran N,N-dimethylformamide | HCID 21974620 | — |
| Produkt | 3-(Imidazo[1,2-b]pyridazin-2-yl)benzonitrile | HCID 53439477 | 88,5% |
Reaktionsschritte
A mixture of 3-(6-chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile (1 mmol) and Pd/C (20 mg) in DMF/THF (10 ml/10 ml) was stirred at r.t. for 6 h equipped with a H2 balloon. Then the solvent was removed under reduced pressure and 3-(imidazo[1,2-b]pyridazin-2-yl)benzonitrile was obtained with a yield of 88.5%.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07868001B2 |
| Quelldatensatz | uspto-grants-2011_01 |
| ORD ID | ord-30420b1878484dd684c15607236eb653 |
| Quellennotiz | uspto-grants-2011_01 |