HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrochloric Acid → 3-(Imidazo[1,2-b]pyridazin-2-yl)benzoic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrochloric Acid | HCID 313 | — |
| Edukt | Ethanol | HCID 702 | — |
| Edukt | Sodium Hydroxide | HCID 14798 | — |
| Edukt | 3-(Imidazo[1,2-b]pyridazin-2-yl)benzonitrile | HCID 53439477 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Produkt | 3-(Imidazo[1,2-b]pyridazin-2-yl)benzoic acid | HCID 57686812 | 60% |
Reaktionsschritte
A solution of 3-(imidazo[1,2-b]pyridazin-2-yl)benzonitrile (1 mmol) and 6M NaOH (2 ml) in EtOH was heated to reflux for 2 h. Then the mixture was diluted with water and acidified with HCl. The precipitate was filtered to give 3-(imidazo[1,2-b]pyridazin-2-yl)benzoic acid with a yield of 60%.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07868001B2 |
| Quelldatensatz | uspto-grants-2011_01 |
| ORD ID | ord-2ba402ee2f5b4b6088104a6e4937924a |
| Quellennotiz | uspto-grants-2011_01 |