Methylhydrazine → 1-Methyl-3-(trifluoromethyl)-1H-pyrazole

HRID 251910

Reaktionsgleichung

Reaktionsgleichung von HRID 251910
C(O[CH:4]=[CH:5][C:6](=O)[C:7]([F:10])([F:9])[F:8])C.[CH3:12][NH:13][NH2:14]>CO>[CH3:12][N:13]1[CH:4]=[CH:5][C:6]([C:7]([F:10])([F:9])[F:8])=[N:14]1

Komponenten

4

Edukt 2

HCID 6061MethylhydrazineHCID 27803954-Ethoxy-1,1,1-trifluoro-3-buten-2-one

Produkt 1

HCID 27804041-Methyl-3-(trifluoromethyl)-1H-pyrazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a mixture of 18 g of 4-ethoxy-1,1,1-trifluoro-3-butene-2-one and 50 ml of methanol was added 5.7 ml of methylhydrazine, and the mixture was heated to reflux for 4 hours. The reaction mixture was allowed to cool to room temperature, concentrated under reduced pressure, and subjected to distillation under reduced pressure (60° C./15 mmHg) to obtain 8.71 g of 1-methyl-3-trifluoromethyl-1H-pyrazole of the formula:

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 4 hours
  3. concentrationconcentrated under reduced pressure
  4. distillationsubjected to distillation under reduced pressure (60° C./15 mmHg)

Quellen und Nachweise

ORD-Eintrag
ord-649b69fbf3864b22ba70a0766c840c75
Quelldatensatz
uspto-grants-2011_01
Patentnummer
US07867949B2

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