Trifluoroacetic acid → 3,4-Dichloro-2-fluorophenol

HRID 252162

Reaktionsgleichung

Reaktionsgleichung von HRID 252162
FC(F)(F)C(O)=O.[Cl:8][C:9]1[C:10]([F:16])=[C:11]([OH:15])[CH:12]=[CH:13][CH:14]=1.[Cl:17]N1C(=O)CCC1=O>C(#N)C>[Cl:8][C:9]1[C:10]([F:16])=[C:11]([OH:15])[CH:12]=[CH:13][C:14]=1[Cl:17]

Komponenten

5

Edukt 3

HCID 6422Trifluoroacetic acidHCID 31398ChlorosuccinimideHCID 27737123-Chloro-2-fluorophenol

Produkt 1

HCID 212741443,4-Dichloro-2-fluorophenolAusbeute 48 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

Trifluoroacetic acid (0.5 mL) was added to a solution of 3-chloro-2-fluorophenol (750 mg, 5.12 mmol) and N-chlorosuccinimide (684 mg, 5.12 mmol) in acetonitrile (30 mL) and the reaction mixture stirred for 24 h. The mixture was concentrated in vacuo and purified by chromatography on silica gel with heptane:EtOAc (9:1, v/v) as eluent to afford the title compound (440 mg, 48%) as a pale yellow solid.

Aufarbeitung

  1. concentrationThe mixture was concentrated in vacuo
  2. custompurified by chromatography on silica gel with heptane:EtOAc (9:1

Quellen und Nachweise

ORD-Eintrag
ord-2b8967049633402ba141b7d6025c334e
Quelldatensatz
uspto-grants-2011_01
Patentnummer
US07868017B2

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