Potassium Carbonate → 1-(2-Amino-3-nitrophenoxy)-2,3-epoxypropane

HRID 25236

Reaktionsgleichung

Reaktionsgleichung von HRID 25236
S(C1C=CC(C)=CC=1)(O[CH2:5][CH:6]1[O:8][CH2:7]1)(=O)=O.[NH2:16][C:17]1[C:22]([N+:23]([O-:25])=[O:24])=[CH:21][CH:20]=[CH:19][C:18]=1[OH:26].C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[NH2:16][C:17]1[C:22]([N+:23]([O-:25])=[O:24])=[CH:21][CH:20]=[CH:19][C:18]=1[O:26][CH2:5][CH:6]1[O:8][CH2:7]1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 160868Glycidyl tosylateHCID 41154952-Amino-3-Nitrophenol

Produkt 1

HCID 113448381-(2-Amino-3-nitrophenoxy)-2,3-epoxypropane

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

21.7 g (0.095 mol) of glycidyl tosylate, 10 g (0.0475 mol) of 2-amino-3-nitrophenol and 6.5 g of crushed K2CO3 are mixed in acetone and the mixture is heated at reflux for 18 hours. The mixture is filtered and the solvent is evaporated under reduced pressure. The crude reaction product is purified by flash chromatography, elution being carried out with a 9/1 hexane/ethyl acetate mixture. The title compound is obtained. M.p.: 7°-78° C.

Aufarbeitung

  1. temperaturethe mixture is heated
  2. temperatureat reflux for 18 hours
  3. filtrationThe mixture is filtered
  4. customthe solvent is evaporated under reduced pressure
  5. customThe crude reaction product
  6. customis purified by flash chromatography, elution

Quellen und Nachweise

ORD-Eintrag
ord-e07988679b094e7aa963e37ef2a90aed
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06858629B1

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