Hydrochloric Acid → HCID 66887928, Verbindung

HRID 252379

Reaktionsgleichung

Reaktionsgleichung von HRID 252379
[CH3:1][O:2][C:3](=[O:13])[C:4]([CH3:12])([C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1)[CH3:5].[ClH:14]>CO.O.[Pt](=O)=O>[ClH:14].[CH3:1][O:2][C:3](=[O:13])[C:4]([CH3:5])([CH:6]1[CH2:11][CH2:10][CH2:9][NH:8][CH2:7]1)[CH3:12]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 54537815HCID 54537815, Verbindung

Produkt 1

HCID 66887928HCID 66887928, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 11139377Platinum dioxide monohydrateKatalysatorHCID 887MethanolLösungsmittel2×

Versuchsvorschrift

A mixture of 0.823 g of 2-methyl-2-pyridin-3-yl-propionic acid methyl ester [476429-23-9] and 0.062 g of platinum(IV) oxide hydrate in 8 ml of methanol and 1.7 ml of 1.2M HCl in methanol at room temperature is hydrogenated for 5.5 hours. The catalyst is removed by filtration over Hyflo and the filtrate is concentrated by evaporation to provide the crude title compound as a brown oil which is used in the next step without further purification.

Aufarbeitung

  1. customThe catalyst is removed by filtration over Hyflo
  2. concentrationthe filtrate is concentrated by evaporation

Quellen und Nachweise

ORD-Eintrag
ord-6d202131da254efb96a29d25c4b84ec3
Quelldatensatz
uspto-grants-2011_01
Patentnummer
US07868036B2

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