1-(Bromomethyl)-4-chlorobenzene → 4-((4-Chlorobenzyl)oxy)-3-fluorobenzaldehyde

HRID 253386Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 253386
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.[F:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][C:18]=1[OH:19])[CH:14]=[O:15]>>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][O:19][C:18]2[CH:17]=[CH:16][C:13]([CH:14]=[O:15])=[CH:12][C:11]=2[F:10])=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 693291-(Bromomethyl)-4-chlorobenzeneHCID 5872503-Fluoro-4-hydroxybenzaldehyde

Produkt 1

HCID 580863304-((4-Chlorobenzyl)oxy)-3-fluorobenzaldehyde

Versuchsvorschrift

Additional aldehydes were prepared using the protocol of Scheme 14, replacing either 4-chlorobenzyl bromide 22 with a suitable alkylating agent, and/or 3-fluoro-4-hydroxy-benzaldehyde 44 with a suitable aldehyde. The following table indicates the alkylating agent (column 1) and the starting aldehyde (column 2) used to afford the aldehyde (column 3) synthesized following this protocol.

Quellen und Nachweise

ORD-Eintrag
ord-01feada5059d43139e39529df3f2287c
Quelldatensatz
uspto-grants-2011_01
Patentnummer
US07872018B2

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