Chloroacetic Acid → 2-(Chloromethyl)-1-methylbenzimidazole

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

N-methyl-phenylenediamine (1 g, 8.2 mmol) and chloroacetic acid (0.9 g, 9.4 mol) were dissolved in 5 N aqueous hydrochloric acid (10 mL) and stirred at 55° C. overnight. The reaction mixture was then diluted with water and basified with solid sodium bicarbonate to give a precipitate which was filtered, washed with water and dried to provide the desired compound (1.3 g, 87%).

Herkunft & Nachweise